Paracetamol in Pregnancy: MHRA Reaffirms Safety Amid Autism Claims
Following recent comments by President Donald Trump suggesting a link between paracetamol use during pregnancy and autism in children, the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has issued a firm rebuttal. The agency confirms that paracetamol remains a safe and recommended option for pain relief during pregnancy when used as directed, and that there is no scientific evidence supporting claims of a causal link to autism.
This article explores the background of the claim, the MHRA’s response, the role of paracetamol in pregnancy care, and the broader implications for public health messaging and misinformation.
The Claim and Its Fallout
On 22 September 2025, President Trump publicly stated that paracetamol (known as Tylenol in the US) may be linked to a “meteoric rise” in autism diagnoses. He suggested that pregnant women should avoid the medication entirely and also raised concerns about vaccines. These remarks sparked immediate backlash from medical experts, autism advocacy groups, and regulatory bodies across the globe.
In the UK, the MHRA responded swiftly, issuing a public statement to reassure pregnant women and healthcare professionals. Dr Alison Cave, Chief Safety Officer at the MHRA, stated:
> “Patient safety is our top priority. There is no evidence that taking paracetamol during pregnancy causes autism in children. Paracetamol remains the recommended pain relief option for pregnant women when used as directed.”
MHRA’s Position: Evidence-Based and Reassuring
The MHRA’s guidance is grounded in decades of scientific research and continuous safety monitoring. Key points from their statement include:
- No causal link: There is no credible evidence that paracetamol use during pregnancy causes autism.
- Recommended treatment: Paracetamol remains the first-line pain relief option for pregnant women, provided it is used at the lowest effective dose and for the shortest necessary duration.
- Risks of untreated symptoms: Pain and fever during pregnancy can pose risks to the unborn baby, making appropriate treatment essential.
- Ongoing surveillance: The MHRA monitors all medicines through robust systems, including the Yellow Card scheme for reporting side effects.
This position aligns with NHS guidance, which also recommends paracetamol as the safest option for managing pain and fever during pregnancy.
Understanding Autism: Facts vs Misinformation
Autism is a lifelong neurodevelopmental condition that affects how people perceive and interact with the world. It is understood as a spectrum, with individuals experiencing a wide range of strengths and challenges. In the UK, over 700,000 people are autistic, and the condition is increasingly recognised and diagnosed thanks to improved awareness and broader diagnostic criteria.
What Causes Autism?
- Genetic factors: Most research points to genetic influences as a key factor.
- No link to vaccines or painkillers: Large-scale studies have repeatedly found no evidence that vaccines or medications like paracetamol cause autism.
- No cure needed: Autism is not a disease to be cured but a difference to be understood and supported.
The National Autistic Society condemned President Trump’s remarks as “dangerous, anti-science, and irresponsible,” warning that such claims risk stigmatising families and undermining decades of research.
The Role of Paracetamol in Pregnancy
Paracetamol is widely used in the UK and globally for its effectiveness and safety profile. During pregnancy, it is often the only recommended over-the-counter painkiller due to its minimal risk when used appropriately.
Why Is It Recommended?
- Low risk: Unlike NSAIDs (e.g., ibuprofen), paracetamol does not carry risks of premature closure of the fetal ductus arteriosus or other complications.
- Effective symptom control: It helps manage common pregnancy symptoms such as headaches, back pain, and fever.
- Accessible and affordable: Paracetamol is widely available and inexpensive, making it a practical choice for most families.
Safe Use Guidelines
- Use the lowest effective dose for the shortest duration.
- Follow the patient information leaflet and NHS guidance.
- Consult a healthcare professional if symptoms persist or worsen.
Combating Misinformation: A Public Health Imperative
The spread of false claims about medicines and autism can have serious consequences:
- Undermining trust: Misinformation erodes public confidence in healthcare systems and professionals.
- Risking health: Avoiding necessary treatment due to fear can lead to complications for both mother and baby.
- Stigmatising autism: Suggesting that autism is caused by parental choices fuels harmful narratives and guilt.
Healthcare professionals, campaigners, and regulators must continue to provide clear, evidence-based information and challenge myths wherever they arise.
What Pregnant Women Should Do
If you are pregnant and experiencing pain or fever:
✅ Take paracetamol as directed by your GP, midwife, or pharmacist
✅ Do not stop treatment based on unverified claims
✅ Report any side effects via the MHRA’s Yellow Card scheme
✅ Use trusted sources like the NHS and MHRA for guidance
✅ Speak to your healthcare provider if you have concerns about any medication
The MHRA’s reaffirmation of paracetamol’s safety during pregnancy is a vital reminder of the importance of evidence-based medicine. In an age of viral misinformation, public health agencies must remain vigilant and proactive in protecting the wellbeing of families.
President Trump’s remarks have reignited a long-standing debate, but the science remains clear: paracetamol, when used correctly, is safe for pregnant women. Autism is not caused by painkillers or vaccines, and spreading such myths only harms those who need support and understanding.
